﻿{"id":21550,"date":"2018-07-18T14:41:08","date_gmt":"2018-07-18T06:41:08","guid":{"rendered":"https:\/\/cdmocmo.ribobio.com\/development\/"},"modified":"2019-08-23T18:52:25","modified_gmt":"2019-08-23T10:52:25","slug":"development","status":"publish","type":"page","link":"https:\/\/cdmocmo.ribobio.com\/en\/development\/","title":{"rendered":"Process Development"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.27.2&#8243; background_color=&#8221;#F2F2F2&#8243; custom_padding=&#8221;0px||0px|&#8221; z_index_tablet=&#8221;500&#8243; box_shadow_horizontal_tablet=&#8221;0px&#8221; box_shadow_vertical_tablet=&#8221;0px&#8221; box_shadow_blur_tablet=&#8221;40px&#8221; box_shadow_spread_tablet=&#8221;0px&#8221; global_module=&#8221;22006&#8243; fb_built=&#8221;1&#8243; bb_built=&#8221;1&#8243; _i=&#8221;0&#8243; _address=&#8221;0&#8243;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; module_class=&#8221;icon_list&#8221; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;||0px|&#8221; _i=&#8221;0&#8243; _address=&#8221;0.0&#8243;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221; _i=&#8221;0&#8243; _address=&#8221;0.0.0&#8243;][et_pb_blurb url=&#8221;\/en\/development\/&#8221; image=&#8221;https:\/\/cdmocmo.ribobio.com\/wp-content\/uploads\/2018\/09\/icon1_0919.png&#8221; module_class=&#8221;icon-quick icon-events&#8221; _builder_version=&#8221;3.27.2&#8243; header_text_align=&#8221;center&#8221; background_size=&#8221;initial&#8221; text_orientation=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;|||&#8221; animation=&#8221;off&#8221; link_option_url=&#8221;\/en\/development\/&#8221; custom_css_after=&#8221;background:#f00|| &#8221; _i=&#8221;0&#8243; _address=&#8221;0.0.0.0&#8243;]<\/p>\n<h6>Oligonucleotide Manufacturing Process Development<\/h6>\n<p>[\/et_pb_blurb][et_pb_blurb url=&#8221;\/en\/analytics-and-chemistry-research\/&#8221; image=&#8221;https:\/\/cdmocmo.ribobio.com\/wp-content\/uploads\/2018\/09\/\u4e34\u5e8a\u7814\u7a76\u7528\u6838\u9178\u836f\u7269\u751f\u4ea7.png&#8221; module_class=&#8221;icon-quick icon-tools&#8221; _builder_version=&#8221;3.27.2&#8243; header_text_align=&#8221;center&#8221; background_size=&#8221;initial&#8221; text_orientation=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;|||&#8221; animation=&#8221;off&#8221; link_option_url=&#8221;\/en\/analytics-and-chemistry-research\/&#8221; custom_css_after=&#8221;background:#f00|| &#8221; _i=&#8221;1&#8243; _address=&#8221;0.0.0.1&#8243;]<\/p>\n<h6>Analytical Methods<br \/> &amp; Stability Study<\/h6>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221; _i=&#8221;1&#8243; _address=&#8221;0.0.1&#8243;][et_pb_blurb url=&#8221;\/en\/clinical-nucleic-acid-drug-manufacture\/&#8221; image=&#8221;https:\/\/cdmocmo.ribobio.com\/wp-content\/uploads\/2018\/09\/icon3_0919.png&#8221; module_class=&#8221;icon-quick icon-resource&#8221; _builder_version=&#8221;3.27.2&#8243; header_text_align=&#8221;center&#8221; background_size=&#8221;initial&#8221; text_orientation=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;|||&#8221; animation=&#8221;off&#8221; link_option_url=&#8221;\/en\/clinical-nucleic-acid-drug-manufacture\/&#8221; custom_css_after=&#8221;background:#f00|| &#8221; _i=&#8221;0&#8243; _address=&#8221;0.0.1.0&#8243;]<\/p>\n<h6>Oligonucleotide<br \/> Manufacturing for Clinical Phases<\/h6>\n<p>[\/et_pb_blurb][et_pb_blurb url=&#8221;\/en\/commercial-oligonucleotides-api-manufacture\/&#8221; image=&#8221;https:\/\/cdmocmo.ribobio.com\/wp-content\/uploads\/2018\/09\/icon9_0919.png&#8221; module_class=&#8221;icon-quick icon-buy&#8221; _builder_version=&#8221;3.27.2&#8243; header_text_align=&#8221;center&#8221; background_size=&#8221;initial&#8221; text_orientation=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;|||&#8221; animation=&#8221;off&#8221; link_option_url=&#8221;\/en\/commercial-oligonucleotides-api-manufacture\/&#8221; custom_css_after=&#8221;background:#f00|| &#8221; _i=&#8221;1&#8243; _address=&#8221;0.0.1.1&#8243;]<\/p>\n<h6>Oligonucleotide<br \/> Manufacturing for Commercial Phases<\/h6>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221; _i=&#8221;2&#8243; _address=&#8221;0.0.2&#8243;][et_pb_blurb url=&#8221;\/en\/drug-product-fill-and-finish\/&#8221; image=&#8221;https:\/\/cdmocmo.ribobio.com\/wp-content\/uploads\/2018\/09\/icon2_0919.png&#8221; module_class=&#8221;icon-quick icon-orders&#8221; _builder_version=&#8221;3.27.2&#8243; header_text_align=&#8221;center&#8221; background_size=&#8221;initial&#8221; text_orientation=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;|||&#8221; animation=&#8221;off&#8221; link_option_url=&#8221;\/en\/drug-product-fill-and-finish\/&#8221; custom_css_after=&#8221;background:#f00|| &#8221; _i=&#8221;0&#8243; _address=&#8221;0.0.2.0&#8243;]<\/p>\n<h6>Preparation, aseptic filling or<br \/> lyophilization<\/h6>\n<p>[\/et_pb_blurb][et_pb_blurb url=&#8221;\/en\/quality-management-system\/&#8221; image=&#8221;https:\/\/cdmocmo.ribobio.com\/wp-content\/uploads\/2018\/09\/icon8_0919.png&#8221; module_class=&#8221;icon-quick icon-user-center&#8221; _builder_version=&#8221;3.27.2&#8243; header_text_align=&#8221;center&#8221; background_size=&#8221;initial&#8221; text_orientation=&#8221;center&#8221; custom_margin=&#8221;0 |||&#8221; custom_padding=&#8221;|||&#8221; animation=&#8221;off&#8221; link_option_url=&#8221;\/en\/quality-management-system\/&#8221; custom_css_after=&#8221;background:#f00|| &#8221; _i=&#8221;1&#8243; _address=&#8221;0.0.2.1&#8243;]<\/p>\n<h6>Validation &amp; Quality<\/h6>\n<p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243; custom_padding=&#8221;54px|0px|11px|0px&#8221; fb_built=&#8221;1&#8243; bb_built=&#8221;1&#8243; _i=&#8221;1&#8243; _address=&#8221;1&#8243;][et_pb_row _builder_version=&#8221;3.25&#8243; border_color_bottom=&#8221;#00AECC&#8221; border_style_bottom=&#8221;none&#8221; custom_margin=&#8221;-30px|||&#8221; custom_padding=&#8221;0||2px|0px&#8221; _i=&#8221;0&#8243; _address=&#8221;1.0&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221; _i=&#8221;0&#8243; _address=&#8221;1.0.0&#8243;][et_pb_text _builder_version=&#8221;3.26.8&#8243; text_text_color=&#8221;#242424&#8243; text_font_size=&#8221;22px&#8221; custom_margin=&#8221;||10px|&#8221; custom_padding=&#8221;|||&#8221; _i=&#8221;0&#8243; _address=&#8221;1.0.0.0&#8243;]<\/p>\n<h1 style=\"font-size: 22px; padding: 0; color: #1e73be;\"><img loading=\"lazy\" class=\"wp-image-242 alignleft size-full\" src=\"http:\/\/ribobio-test.uin88.com\/wp-content\/uploads\/2018\/04\/shuidi.png\" alt=\"\" width=\"18\" height=\"22\" \/>Oligonucleotide Process Development<\/h1>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;0px|0px|10px|0px&#8221; _i=&#8221;1&#8243; _address=&#8221;1.1&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221; _i=&#8221;0&#8243; _address=&#8221;1.1.0&#8243;][et_pb_image src=&#8221;https:\/\/cdmocmo.ribobio.com\/wp-content\/uploads\/2018\/09\/3.jpg&#8221; align_tablet=&#8221;center&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;3.23&#8243; _i=&#8221;0&#8243; _address=&#8221;1.1.0.0&#8243;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;0px|0px|0px|0px&#8221; _i=&#8221;2&#8243; _address=&#8221;1.2&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221; _i=&#8221;0&#8243; _address=&#8221;1.2.0&#8243;][et_pb_text _builder_version=&#8221;3.26.8&#8243; custom_margin=&#8221;||15px|&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;||0px|&#8221; _i=&#8221;0&#8243; _address=&#8221;1.2.0.0&#8243;]<\/p>\n<p style=\"text-align: left;\">Your oligonucleotide manufacturing project is considered unique requiring an individual approach. Therefore, we work closely with you to have a detailed technical discussion to optimize your process, before starting full scale production. Process optimization assures you an oligonucleotide manufactured with the highest yield and purity while minimizing costs.<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.27.2&#8243; text_text_color=&#8221;#1e73be&#8221; custom_margin=&#8221;||2px|&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;||0px|0px&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; hover_enabled=&#8221;0&#8243; _i=&#8221;1&#8243; _address=&#8221;1.2.0.1&#8243;]<\/p>\n<p style=\"text-align: left; margin: 0;\"><strong><a href=\"\/en\/development\/raw-materials-management\/\" target=\"_blank\" style=\"color: #1e73be;\" rel=\"noopener noreferrer\">\u25cf \u00a0\u00a0Raw Material Selection<\/a><\/strong><br \/> <strong><a href=\"\/en\/development\/preparation-of-nucleic-acid-drugs\/\" target=\"_blank\" style=\"color: #1e73be;\" rel=\"noopener noreferrer\">\u25cf \u00a0\u00a0Oligonucleotide Process Development<\/a><\/strong><br \/> <strong><a href=\"\/en\/development\/coupling-process-development\/\" target=\"_blank\" style=\"color: #1e73be;\" rel=\"noopener noreferrer\">\u25cf \u00a0\u00a0Chemical Modification and Coupling Process Development<\/a><\/strong><br \/> <strong><a href=\"\/en\/development\/quality-control-of-process\/\" target=\"_blank\" style=\"color: #1e73be;\" rel=\"noopener noreferrer\">\u25cf \u00a0\u00a0Development of QC methods for processing<\/a><\/strong><br \/> <strong><a href=\"\/en\/development\/production-process-validation\/\" target=\"_blank\" style=\"color: #1e73be;\" rel=\"noopener noreferrer\">\u25cf \u00a0\u00a0Manufacturing Development and Verification<\/a><\/strong><br \/> <strong><a href=\"\/en\/drug-product-fill-and-finish\/\" target=\"_blank\" style=\"color: #1e73be;\" rel=\"noopener noreferrer\">\u25cf \u00a0\u00a0Preparations, aseptic filling or lyophilization<\/a><\/strong><br \/> <strong><a href=\"\/en\/development\/nda-maa-anda\/\" target=\"_blank\" style=\"color: #1e73be;\" rel=\"noopener noreferrer\">\u25cf \u00a0\u00a0CMC Material Writing for IND Application<\/a><\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; 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