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Quality Control Methods for Process Development\u00a0<\/h1>\n[et_pb_section bb_built=”1″ _builder_version=”3.27.2″ background_color=”#F2F2F2″ custom_padding=”0px||0px|” z_index_tablet=”500″ box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” _i=”0″ _address=”0″ next_background_color=”#ffffff” global_module=”22006″][et_pb_row global_parent=”22006″ column_structure=”1_3,1_3,1_3″ module_class=”icon_list” _builder_version=”3.25″ custom_padding=”||0px|” _i=”0″ _address=”0.0″][et_pb_column type=”1_3″ global_parent=”22006″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||” _i=”0″ _address=”0.0.0″][et_pb_blurb global_parent=”22006″ url=”\/en\/development\/” image=”https:\/\/cdmocmo.ribobio.com\/wp-content\/uploads\/2018\/09\/icon1_0919.png” module_class=”icon-quick icon-events” _builder_version=”3.27.2″ header_text_align=”center” background_size=”initial” text_orientation=”center” custom_margin=”|||” custom_padding=”|||” animation=”off” hover_enabled=”0″ custom_css_after=”background:#f00|| ” _i=”0″ _address=”0.0.0.0″ link_option_url=”\/en\/development\/”]<\/p>\n
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Quality Control Methods for Process Development\u00a0<\/h1>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ custom_padding=”0px|0px|8px|0px|false|false”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.26.8″ custom_margin=”||5px|”]<\/p>\n
RiboBio has established a world-class quality control system for the production process of single-chained and double-stranded oligonucleic drugs, CPG, siRNA and chemical modification, and has formed a complete quality control technology standard.<\/p>\n
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\u25cf Solid-phase synthesis process:<\/strong> Online detection of light absorption, flow rate, system pressure, and conductivity change indicators, and real-time monitoring of the reaction of each synthesis cycle, will ensure a smooth reaction process. [\/et_pb_text][et_pb_text _builder_version=”3.26.8″ custom_margin=”||5px|”]<\/p>\n RiboBio also provides development and validation services for nucleic acid drug analysis methods such as product purity, solvent residues, heavy metals, stability, moisture detection, microbial and endotoxin testing.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ _builder_version=”3.22″ background_color=”#F4f4f4″ background_image=”https:\/\/cdmocmo.ribobio.com\/wp-content\/uploads\/2018\/07\/bg_pic3.jpg” border_width_bottom=”2px” border_color_bottom=”#cccccc” custom_padding=”10px|0px|10px|0px|false|false” prev_background_color=”#ffffff” global_module=”21939″][et_pb_row global_parent=”21939″ _builder_version=”3.26.8″][et_pb_column type=”4_4″ global_parent=”21939″ _builder_version=”3.26.8″][et_pb_button global_parent=”21939″ button_url=”\/en\/cro-cdmo-service-for-nucleic-acid-drugs\/” button_text=”Quote for CDMO service” button_alignment=”center” _builder_version=”3.26.8″ \/][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" [et_pb_section bb_built=”1″ _builder_version=”3.27.2″ background_color=”#F2F2F2″ custom_padding=”0px||0px|” z_index_tablet=”500″ box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” _i=”0″ _address=”0″ next_background_color=”#ffffff” global_module=”22006″][et_pb_row global_parent=”22006″ column_structure=”1_3,1_3,1_3″ module_class=”icon_list” _builder_version=”3.25″ custom_padding=”||0px|” _i=”0″ _address=”0.0″][et_pb_column type=”1_3″ global_parent=”22006″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||” _i=”0″ _address=”0.0.0″][et_pb_blurb global_parent=”22006″ url=”\/en\/development\/” image=”https:\/\/cdmocmo.ribobio.com\/wp-content\/uploads\/2018\/09\/icon1_0919.png” module_class=”icon-quick icon-events” _builder_version=”3.27.2″ header_text_align=”center” background_size=”initial” text_orientation=”center” custom_margin=”|||” custom_padding=”|||” animation=”off” hover_enabled=”0″ custom_css_after=”background:#f00|| ” _i=”0″ _address=”0.0.0.0″ link_option_url=”\/en\/development\/”] Oligonucleotide Manufacturing Process Development [\/et_pb_blurb][et_pb_blurb global_parent=”22006″ url=”\/en\/analytics-and-chemistry-research\/” image=”https:\/\/cdmocmo.ribobio.com\/wp-content\/uploads\/2018\/09\/\u4e34\u5e8a\u7814\u7a76\u7528\u6838\u9178\u836f\u7269\u751f\u4ea7.png” module_class=”icon-quick […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":21550,"menu_order":93,"comment_status":"closed","ping_status":"closed","template":"page-hsy.php","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":""},"_links":{"self":[{"href":"https:\/\/cdmocmo.ribobio.com\/en\/wp-json\/wp\/v2\/pages\/21570"}],"collection":[{"href":"https:\/\/cdmocmo.ribobio.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cdmocmo.ribobio.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cdmocmo.ribobio.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cdmocmo.ribobio.com\/en\/wp-json\/wp\/v2\/comments?post=21570"}],"version-history":[{"count":7,"href":"https:\/\/cdmocmo.ribobio.com\/en\/wp-json\/wp\/v2\/pages\/21570\/revisions"}],"predecessor-version":[{"id":22086,"href":"https:\/\/cdmocmo.ribobio.com\/en\/wp-json\/wp\/v2\/pages\/21570\/revisions\/22086"}],"up":[{"embeddable":true,"href":"https:\/\/cdmocmo.ribobio.com\/en\/wp-json\/wp\/v2\/pages\/21550"}],"wp:attachment":[{"href":"https:\/\/cdmocmo.ribobio.com\/en\/wp-json\/wp\/v2\/media?parent=21570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\u25cf Ammonia\/deprotection process:<\/strong> The control of reaction end point is achieved through the monitor of high performance liquid chromatography (HPLC), ultra high pressure liquid chromatography (UPLC), mass spectrometry (MS), and ultraviolet absorption (UV) of the mother liquor.
\u25cf Purification and refining process:<\/strong> To confirm the structure and purity of the target after the product fractions has been detected by HPLC, UPLC, MS and UV, and to serve as a refernce to the mixed sample of the final product.
\u25cf Desalination process:<\/strong> The product is detected by conductivity, HPLC, UPLC, MS, and UV detection to monitor the desalination process.
\u25cf Annealing process:<\/strong> The mixing ratio of two single chains is monitored by size exclusion chromatography (SEC) to ensure that the double strands form a 1:1 ratio.<\/p>\n